Our products are used worldwide in daily patient care, as well as in research on innovative techniques and therapies.

Working together with doctors and scientists, we develop new ideas in the fields of intraoperative neuromonitoring, functional neurosurgery and pain treatment.

Today and in future, our focus is on the patients' safety.


Cortical and subcortical mapping:

Introduction of a novel connection clip for the ultrasonic aspirator for subcortical continuous motor mapping

  • Brain Spine. 2021 Jul 28;1:100002. doi: 10.1016/j.bas.2021.100002. eCollection 2021.
    Colette Boëx, Cristina Goga, Nadia Bérard, Julien Haemmerli, Gregory Zegarek, Andrea Bartoli, Shahan Momjian, Karl Schaller
    PMID: 36247400 PMCID: PMC9559965 DOI: 10.1016/j.bas.2021.100002 PMID: 36247400 PMCID: PMC9559965 DOI: 10.1016/j.bas.2021.100002

Middle Frontal Gyrus and Area 55b: Perioperative Mapping and Language Outcomes

  • Front Neurol. 2021 Mar 10;12:646075. doi: 10.3389/fneur.2021.646075. eCollection 2021.
    Sally Rosario Hazem, Mariam Awan, Jose Pedro Lavrador, Sabina Patel, Hilary Margaret Wren, Oeslle Lucena, Carla Semedo, Hassna Irzan, Andrew Melbourne, Sebastien Ourselin, Jonathan Shapey, Ahilan Kailaya-Vasan, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani
    PMID: 33776898 PMCID: PMC7988187 DOI: 10.3389/fneur.2021.646075

How many patients require brain mapping in an adult neuro-oncology service?

  • Neurosurg Rev. 2020 Apr;43(2):729-738. doi: 10.1007/s10143-019-01112-5. Epub 2019 May 19. Anastasios Giamouriadis, Jose Pedro Lavrador, Ranjeev Bhangoo, Keyoumars Ashkan, Francesco Vergani PMID: 31104183 DOI: 10.1007/s10143-019-01112-5


Evoked potentials:

Optimization of signal-to-noise ratio in short-duration SEP recordings by variation of stimulation rate

  • Clinical Neurophysiology Volume 150, June 2023, Pages 89-97
    Vasileios Dimakopoulos, Giorgio Selmin, Luca Regli, Johannes Sarnthein
    PMID: 37030046; DOI: 10.1016/j.clinph.2023.03.008;

Improving intraoperative evoked potentials at short latency by a novel neuro-stimulation technology with delayed return discharge

  • Clin Neurophysiol . 2021 Jun;132(6):1195-1199.
    doi: 10.1016/j.clinph.2021.02.396. Epub 2021 Apr 7.
    Johannes Sarnthein  1 , Michael Tomilov  2 , Matthias Baag  2 , Luca Regli  3
    PMID: 33895054 DOI: 10.1016/j.clinph.2021.02.396

Reliability of Intraoperative Monitoring in Patients with a Preexisting Motor Deficit: Case Report and Literature Review

  • J Neurol Surg A Cent Eur Neurosurg. 2021 Jul;82(4):387-391. doi: 10.1055/s-0039-1698396. Epub 2020 Mar 28.
    Ravindran Visagan, José Pedro Lavrador, Shami Acharya, Noemia Pereira, Istvan Bodi, Keyoumars Ashkan, Ranjeev Bhangoo, F Vergani
    PMID: 32221963 DOI: 10.1055/s-0039-1698396

Long-term motor deficit in brain tumour surgery with preserved intra-operative motor-evoked potentials

  • Davide Giampiccolo, Cristiano Parisi, Pietro Meneghelli, Vincenzo Tramontano, Federica Basaldella, Marco Pasetto , Giampietro Pinna, Luigi Cattaneo, Francesco Sala
    PMID: 33615216 PMCID: PMC7884605 DOI: 10.1093/braincomms/fcaa226

Evaluation of the High-Frequency Monopolar Stimulation Technique for Mapping and Monitoring the Corticospinal Tract in Patients With Supratentorial Gliomas. A Proposal for Intraoperative Management Based on Neurophysiological Data Analysis [...]

  • [...] in a Series of 92 Patients
    Neurosurgery. 2017 Oct 1;81(4):585-594. doi: 10.1093/neuros/nyw087.
    Gerard Plans, Isabel Fernández-Conejero, Xavier Rifà-Ros, Alejandro Fernández-Coello, Aleix Rosselló , Andreu Gabarrós
    PMID: 28327942 DOI: 10.1093/neuros/nyw087

Predictive value and safety of intraoperative neurophysiological monitoring with motor evoked potentials in glioma surgery

  • Neurosurgery. 2012 May;70(5):1060-70; discussion 1070-1. doi: 10.1227/NEU.0b013e31823f5ade.
    Sandro M Krieg, Ehab Shiban, Doris Droese, Jens Gempt, Niels Buchmann, Haiko Pape, Yu-Mi Ryang, Bernhard Meyer, Florian Ringel
    PMID: 22067415 DOI: 10.1227/NEU.0b013e31823f5ade

Recordings of long-latency trigeminal somatosensory-evoked potentials in patients under general anaesthesia

  • Clin Neurophysiol. 2011 May;122(5):1048-54.doi: 10.1016/j.clinph.2010.08.017. Epub 2010 Oct 20.
    Michael Jörg Malcharek, Janett Landgraf, Gerd Hennig, Oliver Sorge, Juliane Aschermann, Armin Sablotzki
    PMID: 20965778 DOI: 10.1016/j.clinph.2010.08.017

Transcranial electric stimulation for intraoperative motor evoked potential monitoring: Stimulation parameters and electrode montages

  • Clin Neurophysiol. 2007 Jul;118(7):1586-95. doi: 10.1016/j.clinph.2007.04.008. Epub 2007 May 15.
    Andrea Szelényi, Karl F Kothbauer, Vedran Deletis
    PMID: 17507288 DOI: 10.1016/j.clinph.2007.04.008

Improved potential quality of intraoperative transcranial motor-evoked potentials by navigated electrode placement compared to the conventional ten-twenty system

  • Wagner, Arthur, Sebastian Ille, Caspar Liesenhoff, Kaywan Aftahy, Bernhard Meyer, und Sandro M. Krieg. Neurosurgical Review 45, Nr. 1 (2022): 585–93.

Transcranial versus direct electrical stimulation for intraoperative motor-evoked potential monitoring: Prognostic value comparison in asleep brain tumor surgery

  • Viganò, Luca, Vincenzo Callipo, Marta Lamperti, Marco Rossi, Marco Conti Nibali, Tommaso Sciortino, Lorenzo Gay, u. a. Frontiers in Oncology 12 (29. September 2022): 963669.

Evaluation of a New Cortical Strip Electrode for Intraoperative Somatosensory Monitoring during Perirolandic Brain Surgery

  • Sarnthein, Johannes, Kathleen Seidel, Marian Christoph Neidert, Andreas Raabe, Francesco Sala, Joerg Christian Tonn, Niklas Thon, und Andrea Szelenyi. Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 142 (Oktober 2022): 44–51.

Transcranial Electrical Stimulation Elicits Short and Long Latency Responses in the Tongue Muscles


Infratentorial surgery:

Long latency responses in tongue muscle elicited by various stimulation sites in anesthetized humans - New insights into tongue-related brainstem reflexes

  • Brain Stimul. 2022 May-Jun;15(3):566-575.doi: 10.1016/j.brs.2022.03.003. Epub 2022 Mar 24.
    Andrea Szelényi, Enrica Fava
    PMID: 35341967 DOI: 10.1016/j.brs.2022.03.003

Neuromonitoring During Robotic Cochlear Implantation: Initial Clinical Experience

  • Ann Biomed Eng. 2018 Oct;46(10):1568-1581. doi: 10.1007/s10439-018-2094-7. Epub 2018 Jul 26.
    Juan Ansó, Olivier Scheidegger, Wilhelm Wimmer, Kate Gavaghan, Nicolas Gerber, Daniel Schneider, Jan Hermann, Christoph Rathgeb, Cilgia Dür, Kai Michael Rösler, Georgios Mantokoudis, Marco Caversaccio, Stefan Weber
    PMID: 30051248 DOI: 10.1007/s10439-018-2094-7

Poor diagnostic accuracy of transcranial motor and somatosensory evoked potential monitoring during brainstem cavernoma resection

  • Acta Neurochir (Wien). 2015 Nov;157(11):1963-9; discussion 1969. doi: 10.1007/s00701-015-2573-7. Epub 2015 Sep 7.
    Ehab Shiban, Marina Zerr, Thomas Huber, Tobias Boeck-Behrends, Maria Wostrack, Florian Ringel, Bernhard Meyer, Jens Lehmberg
    PMID: 26347046 DOI: 10.1007/s00701-015-2573-7

Superiority of tympanic ball electrodes over mastoid needle electrodes for intraoperative monitoring of hearing function

  • J Neurosurg. 2014 May;120(5):1042-7. doi: 10.3171/2014.1.JNS13396. Epub 2014 Feb 21.
    Sandro M Krieg, Lisa Kempf, Doris Droese, Steffen K Rosahl, Bernhard Meyer, Jens Lehmberg
    PMID: 24559226 DOI: 10.3171/2014.1.JNS13396

Facial nerve motor evoked potentials during skull base surgery to monitor facial nerve function using the threshold-level method

  • Neurosurg Focus. 2013 Mar;34(3):E7. doi: 10.3171/2012.12.FOCUS12386.
    Johannes Sarnthein, Nader Hejrati, Marian C Neidert, Alexander M Huber, Niklaus Krayenbühl
    PMID: 23451854 DOI: 10.3171/2012.12.FOCUS12386

Monitoring motor function during resection of tumours in the lower brain stem and fourth ventricle

  • Childs Nerv Syst. 2006 Oct;22(10):1288-95. doi: 10.1007/s00381-006-0101-z. Epub 2006 May 13.
    Sven Gläsker, Ulrich Pechstein, Vassilios I Vougioukas, Vera Van Velthoven
    PMID: 16699805 DOI: 10.1007/s00381-006-0101-z

Intra-operative electromyographic monitoring of the lower cranial motor nerves (LCN IX-XII) in skull base surgery

  • Clin Neurol Neurosurg. 2001 Jul;103(2):72-82. doi: 10.1016/s0303-8467(01)00115-9.
    Intra-operative electromyographic monitoring of the lower cranial motor nerves (LCN IX-XII) in skull base surgery
    H P Schlake, R H Goldbrunner, C Milewski, J Krauss, H Trautner, R Behr, N Sörensen, J Helms, K Roosen
    PMID: 11516548 DOI: 10.1016/s0303-8467(01)00115-9

Quantitative parameters of intraoperative electromyography predict facial nerve outcomes for vestibular schwannoma surgery

  • Neurosurgery. 2000 May;46(5):1140-6; discussion 1146-8. doi: 10.1097/00006123-200005000-00023.
    R H Goldbrunner, H P Schlake, C Milewski, J C Tonn, J Helms, K Roosen
    PMID: 10807246 DOI: 10.1097/00006123-200005000-00023

Bilateral and Optimistic Warning Paradigms Improve the Predictive Power of Intraoperative Facial Motor Evoked Potentials during Vestibular Schwannoma Surgery

  • Greve, Tobias, Liang Wang, Sophie Katzendobler, Lucas L. Geyer, Christian Schichor, Jörg Christian Tonn, und Andrea Szelényi. Cancers 13, Nr. 24 (9. Dezember 2021): 6196.


Vascular surgery:

Motor evoked potentials during revascularization in ischemic stroke predict motor pathway ischemia and clinical outcome

  • Clin Neurophysiol. 2020 Sep;131(9):2307-2314.doi: 10.1016/j.clinph.2020.05.026. Epub 2020 Jun 18.
    Tobias Greve, Arthur Wagner, Sebastian Ille, Silke Wunderlich, Benno Ikenberg, Bernhard Meyer, Claus Zimmer, Ehab Shiban, Kornelia Kreiser
    PMID: 32622586 DOI: 10.1016/j.clinph.2020.05.026

Brain tissue oxygenation monitoring supplementary to somatosensory evoked potential monitoring for aneurysm surgery. Initial clinical experience

  • Neurol Res. 2002 Sep;24(6):555-62. doi: 10.1179/016164102101200528.
    Andrea Szelényi, Carla S Jung, Holger Schön, Volker Seifert
    PMID: 12238620 DOI: 10.1179/016164102101200528

Impact of Intermittent Functional Internal Iliac Artery Occlusion on Spinal Cord Blood Supply during TEVAR

  • Thorac Cardiovasc Surg. 2020 Jun;68(4):315-321. doi: 10.1055/s-0039-1688474. Epub 2019 May 15.
    Sven Maier, Julia Morlock, Christoph Benk, Fabian Alexander Kari, Matthias Siepe , Friedhelm Beyersdorf, Martin Czerny, Bartosz Rylski
    PMID: 31091550 DOI: 10.1055/s-0039-1688474

Warning criteria for MEP monitoring during carotid endarterectomy: a retrospective study of 571 patients

  • J Clin Monit Comput. 2020 Jun;34(3):589-595. doi: 10.1007/s10877-019-00345-5. Epub 2019 Jul 2.
    Michael J Malcharek, Judith Hesse, Kristin Hesselbarth, Kathrin Thoma, Celine Wegner, Armin Sablotzki, Gert Hennig, Jochen Gille
    PMID: 31267409 DOI: 10.1007/s10877-019-00345-5

The Morphology of Somatosensory Evoked Potentials During Middle Cerebral Artery Aneurysm Clipping (MoSAC): A Pilot Study

  • Clin EEG Neurosci 2020 Mar;51(2):130-136. doi: 10.1177/1550059419874942. Epub 2019 Sep 12.
    Franca Tecchio, Federico Cecconi, Elisabetta Colamartino, Matteo Padalino, Luca Valci, Michael Reinert
    PMID: 31514539 DOI: 10.1177/1550059419874942

Predictive value of transcranial evoked potentials during mechanical endovascular therapy for acute ischaemic stroke: a feasibility study

  • J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):598-603. doi: 10.1136/jnnp-2015-310649. Epub 2015 Jun 10.
    Ehab Shiban, Silke Wunderlich, Kornelia Kreiser, Jens Lehmberg, Bernhard Hemmer, Sascha Prothmann, Claus Zimmer, Bernhard Meyer, Florian Ringel
    PMID: 26063929 DOI: 10.1136/jnnp-2015-310649

Multimodal evoked potential monitoring in asleep patients versus neurological evaluation in awake patients during carotid endarterectomy: a single-centre retrospective trial of 651 patients

  • Minerva Anestesiol. 2015 Oct;81(10):1070-8. Epub 2015 Feb 6.
    M J Malcharek, V Herbst, G J Bartz, A M Manceur, J Gille, G Hennig, A Sablotzki, G Schneider
    PMID: 25658171

Perioperative management to improve neurologic outcome in thoracic or thoracoabdominal aortic stent-grafting

  • Ann Thorac Surg. 2006 Nov;82(5):1679-87. doi: 10.1016/j.athoracsur.2006.05.037.
    Ernst Weigang, Marc Hartert, Michael P Siegenthaler, Nicholas A Beckmann, Ronen Sircar, Gàbor Szabò, Christian D Etz, Maximilian Luehr, Patrick von Samson, Friedhelm Beyersdorf
    PMID: 17062227 DOI: 10.1016/j.athoracsur.2006.05.037

Neurophysiological monitoring during thoracoabdominal aortic endovascular stent graft implantation

  • Eur J Cardiothorac Surg. 2006 Mar;29(3):392-6. doi: 10.1016/j.ejcts.2005.11.039. Epub 2006 Jan 24.
    Ernst Weigang, Marc Hartert, Michael P Siegenthaler, Katrin Pitzer-Hartert, Maximilian Luehr, Ronen Sircar, Patrick von Samson, Friedhelm Beyersdorf
    PMID: 16439144 DOI: 10.1016/j.ejcts.2005.11.039

Improved spinal cord perfusion during thoracoabdominal aortic repair

  • Thorac Cardiovasc Surg. 2005 Apr;53(2):69-73. doi: 10.1055/s-2004-830521.
    E Weigang, M Hartert, P von Samson, U Pechstein, J Genstorfer, K Pitzer, J Zentner, F Beyersdorf
    PMID: 15786003 DOI: 10.1055/s-2004-830521

Evozierte Potentiale in der Aortenchirurgie

  • August 2005, Zeitschrift für Herz- Thorax- und Gefäßchirurgie 19(4):149-155 DOI:10.1007/s00398-005-0507-z
    Jörg Genstorfer, Marc Hartert, Patrick von Samson, Katrin Pitzer, Ronen Sircar, Maximilian Luehr, Friedhelm Beyersdorf, Ernst Weigang

Setup of neurophysiological monitoring with tcMEP/SSEP during thoracoabdominal aneurysm repair

  • Thorac Cardiovasc Surg. 2005 Feb;53(1):28-32. doi: 10.1055/s-2004-830431. E Weigang, M Hartert, R Sircar, P V Samson, K Pitzer, J Genstorfer, J Zentner, F Beyersdorf PMID: 15692915 DOI: 10.1055/s-2004-830431



The rhythm of the executive gate of speech: subthalamic low-frequency oscillations increase during verbal generation

  • Eur J Neurosci. 2017 May;45(9):1200-1211. doi: 10.1111/ejn.13429. Epub 2016 Oct 31.
    Lars Wojtecki, Saskia Elben, Jan Vesper, Alfons Schnitzler PMID: 27718535 DOI: 10.1111/ejn.13429

Detectability of the somatosensory evoked high frequency oscillation (HFO) co-recorded by scalp EEG and ECoG under propofol

  • Neuroimage Clin. 2015 Dec 14;10:318-25. doi: 10.1016/j.nicl.2015.11.018. eCollection 2016.
    Sergey Burnos, Tommaso Fedele, Olivier Schmid, Niklaus Krayenbühl, Johannes Sarnthein
    PMID: 26900572 PMCID: PMC4723731 DOI: 10.1016/j.nicl.2015.11.018

Intraoperative risk of seizures associated with transient direct cortical stimulation in patients with symptomatic epilepsy

  • J Clin Neurophysiol. 2007 Feb;24(1):39-43. doi: 10.1097/01.wnp.0000237073.70314.f7. Andrea Szelényi, Boban Joksimovic, Volker Seifert
    PMID: 17277576 DOI: 10.1097/01.wnp.0000237073.70314.f7