ISIS Neurostimulator

New possibilities in IOM: The ISIS neurostimulator with stimulation artifact suppression

The ISIS Neurostimulator's flexible, unique and US patented technology has been specifically designed to meet the most demanding requirements of intraoperative neuromonitoring. >>

> High current and direct nerve stimulation with monophasic, biphasic and alternating pulse forms
Use as a single device or as part of the ISIS IOM system >> via the integrated NeuroExplorer software >>
Continuous impedance control of the stimulation electrodes during the operation

Stimulation artifact suppression

With the newly developed and German patented technology for the suppression of the stimulation artifact, signals with short latency and low amplitude can be displayed more clearly. Whether D-wave or corticobulbar MEPs, less superimposition makes it easier to identify the signals.

Maximum flexibility with the ISIS neurostimulator

The 12 channels for high current stimulation (max. 250 mA) and one channel for direct nerve stimulation (max. 25 mA) allow the use of different neurophysiological measurement methods in neurosurgery, epilepsy surgery, general and visceral surgery as well as otorhinolaryngology.



Easy and safe to handle

Stimulation and discharge adaptor for electrode connection:

> The adaptor boxes connecting the electrodes to the ISIS neurostimulator for neurostimulation are simple and safe to use - thanks to color-coded slots, plug connections and cables.
> A clear and distinct marking speeds up the connection of the electrode.
> If required the connection to a neurodiagnostic system is possible. The results of neurostimulation can be displayed and documented in the form of EMG or iEEG signals.


Publication: “Improving intraoperative evoked potentials at short latency by a novel neurostimulation technology with delayed return discharge“ by J. Sarnthein et al. >>


  • Stimulation artifact suppression
  • Constant current stimulator with 12+1 flexible outputs for direct nerval, cortical, muscular, transcutaneous and transcranial electrical neurostimulation
  • Stimulation current adjustable from 0.01mA to 250mA in individually definable steps
  • Impedance measurement and current flow control display
  • Simple programming of an unlimited number of application-specific stimulation programs
  • Patient database for documentation

Application Fields of Neurostimulation

  • Transcranial electrical neurostimulation for motor evoked potentials
  • Direct cortical and subcortical neurostimulation of the speech and motor cortex
  • Direct intracerebral neurostimulation for localization of functional disorders in pre-surgical epilepsy diagnostics
  • Direct nerve stimulation for monitoring of cranial and peripheral nerves including nerve action potential measurements
  • Nerve and muscle stimulation for pelvic and anal atresia surgery

More information >